My laboratory engineers genetic systems that go beyond what nature’s genetic systems can do. We are especially interested in creating genetic systems that dramatically accelerate the speed of evolution and that record transient information as interpretable mutations in DNA. We apply these systems to the generation of useful biomolecules and therapeutics; the study of molecular evolution; and cell and developmental biology. I will discuss recent work on our orthogonal DNA replication system for the continuous evolution of biomolecules in vivo.