|The Valentine Lab at the University of California, Santa Barbara
Molecular & Cellular Biomechanics
MEGAN T. VALENTINE
Assistant Professor of Mechanical Engineering, University of California, Santa Barbara CA (2008-present)
Postdoctoral Researcher, Department of Biology, Stanford University, Stanford, CA (2003-2008)
Advisor: Steven M. Block, Departments of Applied Physics and Biology
EDUCATION:Ph.D. Physics, Harvard University, Cambridge, MA (1999–2003)
Thesis topic: Mechanical and microstructural properties of biological materials
Advisor: David A. Weitz, Department of Physics
M.S. Physics, University of Pennsylvania, Philadelphia, PA (1997–99)
Advisor: David A. Weitz, Department of Physics
B.S. Physics, Lehigh University, Bethlehem, PA (1993–97; highest honors)
Advisor: H. Daniel Ou-Yang, Department of Physics
Minor: Science Writing
HONORS & AWARDS
- NSF CAREER Award, 2013
- University of California, Santa Barbara, Faculty Career Development Award, 2012
- Regents Junior Faculty Fellowship, University of California, Santa Barbara, 2010
- University of California, Santa Barbara, Faculty Career Development Award, 2009
- Career Award at the Scientific Interface, Burroughs Wellcome Fund, 2005
- Fellowship Award, Damon Runyon Cancer Research Foundation, 2004
- Wallace-Noyes Fellowship, Harvard University, Department of Physics, 2002
- Travel Grants: Society of Rheology, 2001; American Chemical Society, 2001; van Vleck Grant from the Department of Physics, Harvard University, 2000
- Waldo Semon Award for excellence in undergraduate research in polymer science, 1997
- Alex J. Weinstein Memorial Scholarship, 1995-97
- Harold S. and Melda A. Mohler Memorial Scholarship, 1995-97
- National Science Scholar, 1993-95
- Lehigh University Scholarship, 1993-97
- Member, Sigma Xi, Phi Beta Kappa
PUBLICATIONS (Available via Google Scholar)
- Dezhi Yu, Veronica Pessino, Steve Kuei, and Megan T. Valentine. “Mechanical and functional properties of epothilone-stabilized microtubules,” Cytoskeleton in press.
- Bugra Kaytanli and Megan T. Valentine. “Evolute-based Hough transform method for characterization of ellipsoids,” Journal of Microscopy in press.
- Yali Yang, Mo Bai, William S. Klug, Alex J. Levine and Megan T. Valentine. “Microrheology of highly crosslinked microtubule networks is dominated by force-induced crosslinker unbinding,” Soft Matter 9 383-393 (2013).
- David Valdman, Benjamin J. Lopez, Megan T. Valentine, and Paul J. Atzberger. “Force spectroscopy of complex biopolymers with heterogeneous elasticity,” Soft Matter 9 772-778 (2013).
- Jun Lin and Megan T. Valentine. “High-force NdFeB-based magnetic tweezers device optimized for microrheology experiments,” Review of Scientific Instruments 83 053905 (2012).
- Jun Lin and Megan T. Valentine. “Ring-shaped NdFeB-based magnetic tweezers enables oscillatory microrheology measurements,” Applied Physics Letters 100 201902 (2012).
- David Valdman, Paul J. Atzberger, Dezhi Yu, Steve Kuei and Megan T. Valentine. “Spectral Analysis Methods for the Robust Measurement of the Flexural Rigidity of Biopolymers,” Biophysical Journal 102(5) 1144-1153 (2012).
- Yali Yang*, Jun Lin*, Bugra Kaytanli, Omar Saleh and Megan T. Valentine. “Direct correlation between creep compliance and deformation in entangled and sparsely crosslinked microtubule networks,” Soft Matter 8 1776-1784 (2012).
- Yali Yang*, Jun Lin*, Ryan Meschewski, Erin Watson, and Megan T. Valentine. “Portable magnetic tweezers device enables visualization of the three-dimensional microscale deformation of soft biological materials,” BioTechniques 51 29-34 (2011).
- M.T. Valentine and Steven M. Block. “Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers,” Biophysical Journal 97 1671-7 (2009).
- Michael T. Woodside and Megan T. Valentine. (2009) “Single-molecule manipulation using optical traps,” in Handbook of Single-Molecule Biophysics, eds. Peter Hinterdorfer and Antoine Van Oijen. New York, NY: Springer.
- Megan T. Valentine*, Nicholas R. Guydosh*, Braulio Gutiérrez-Medina*, Adrian N. Fehr*, Johan O. Andreasson*, and Steven M. Block. “Precision steering of an optical trap by electro-optic deflection,” Optics Letters 33 599-601 (2008).
- Megan T. Valentine and Susan P. Gilbert. “To Step or Not to Step? How Biochemistry and Mechanics Influence Processivity in Kinesin and Eg5,” Current Opinion in Cell Biology 19 75-81 (2007).
- Polly M. Fordyce*, Megan T. Valentine* and Steven M. Block. 2007. “Advances in surface-based assays for single molecules,” in Single-Molecule Techniques: A Laboratory Manual, eds. Paul Selvin and Taekjip Ha. Woodbury, NY: Cold Spring Harbor Laboratory Press.
- Megan T. Valentine, Polly M. Fordyce, and Steven M. Block. “Eg5 steps it up!,” Cell Division 1 31 (2006).
- Megan T. Valentine*, Polly M. Fordyce*, Troy C. Krzysiak, Susan P. Gilbert, Steven M. Block. “Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro,” Nature Cell Biology 8 470 (2006).
- M.T. Valentine, Z.E. Perlman, T.J. Mitchison, and D.A. Weitz. “Mechanical properties of Xenopus egg cytoplasmic extracts,” Biophysical Journal 88 680 (2005).
- M.L. Gardel, M.T. Valentine, and D.A. Weitz. (2005) “Microrheology” in Microscale Diagnostic Techniques ed. K. Breuer. New York: Springer-Verlag.
- M.T. Valentine, Z.E. Perlman, M.L. Gardel, J.H. Shin, P. Matsudaira, T.J. Mitchison, and D.A. Weitz. “Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials,” Biophysical Journal 86 4004-14 (2004).
- I.Y. Wong, M.L. Gardel, David R. Reichman, Eric R. Weeks, M.T. Valentine, A.R. Bausch, D.A. Weitz. “Anomalous diffusion probes microstructure dynamics of entangled F-actin networks,” Physical Review Letters 92 178101 (2004).
- M.L. Gardel, M.T. Valentine, J.C. Crocker, A.R. Bausch, and D.A. Weitz. “Microrheology of entangled F-actin solutions,” Physical Review Letters 91 158302 (2003).
- Vernita D. Gordon, M.T. Valentine, M.L. Gardel, Daniel Andor, Samantha Dennison, Alexei A. Bogdanov, D.A. Weitz, and Thomas S. Deisboeck. “Measuring the mechanical stress induced by a dynamically expanding multicellular tumor system within a three-dimensional in vitro assay,” Experimental Cell Research 289 58 (2003).
- A.K. Popp, M.T. Valentine, P.D. Kaplan, D.A. Weitz. “On the microscopic origins of light scattering in tissue,” Applied Optics 42 2871 (2003).
- M.T. Valentine, A.K. Popp, P.D. Kaplan, and D.A. Weitz. “Microscope-based static light scattering instrument,” Optics Letters 26 890 (2001).
- M.T. Valentine, P.D. Kaplan, D. Thota, J.C. Crocker, T. Gisler, R.K. Prud’homme, M. Beck, and D.A. Weitz. “Investigating the microenvironments of inhomogeneous soft materials with multiple particle tracking,” Physical Review E 64 061506 (2001).
- M.T. Valentine, A.K. Popp, P.D. Kaplan, and D.A. Weitz “Microscope-based static light scattering instrument enables precise measurements of heterogeneous materials,” Optics and Photonics News 12 37 (2001).
[Edition highlights 200 of the most exciting new optics innovations of the year.]
- A.K. Popp, M.T. Valentine, P.D. Kaplan, and D.A. Weitz. “Light scattering microscope as a tool to investigate scattering heterogeneity in tissue,” Proceedings of the SPIE, Optical Biopsy III Conference, San Jose, CA, Robert R. Alfano, Ed. 3917 22 (2000).
- John C. Crocker, M.T. Valentine, Eric R. Weeks, T. Gisler, P.D. Kaplan, A.G. Yodh, and D.A. Weitz. “Two-point microrheology of inhomogeneous soft materials,” Physical Review Letters 85 888 (2000).
- M.T. Valentine, L.E. Dewalt, and H.D. Ou-Yang. “Forces on a colloidal particle in a polymer solution: a study using optical tweezers,” Journal of Physics: Condensed Matter (U.K.). 8 9477 (1996).
* indicates equal contribution
- Seminar, Cancer Research UK, London Research Institute, December, 2012
- Seminar, Center for Biological Physics, UCLA, October, 2012
- Seminar, Department of Physics, Emory University, September, 2012
- Invited Speaker, American Physical Society March Meeting, March, 2012
- Lecturer, Biophysics Winter School, ETH Conference Center, Locarno Switzerland, January, 2012
- Invited Speaker,Biomechanics 2012, ICAM conference. Mechanics in Biology: From single molecules to tissues. Los Angeles, January 2012
- Seminar, Biomechanics Research Seminar, University of California, San Diego, October 2011
- Invited Speaker, KAIST Workshop on multiscale materials, Daejeon Korea, August 2011
- Seminar, Department of Physics, University of California, Los Angeles, March 2011
- Seminar, Department of Physics, University of Chicago, Chicago, July 2010
- Seminar, Biophysics Research Division, FOM Institute - AMOLF, Amsterdam, The Netherlands, March 2010
- Seminar, Department of Physics, California Polytechnic State University, San Luis Obispo, March 2009
- Seminar, Institute for Stem Biology and Medicine, University of California, Los Angeles, February 2007
- Seminar, Department of Applied Physics, California Institute of Technology, January 2007
- Seminar, Department of Physics, University of Michigan, January 2007
- Seminar, Department of Bioengineering, University of California, San Diego, December 2006
- Seminar, Department of Biochemistry and Biophysics, University of Pennsylvania, November 2006
- Invited Speaker, Single-molecule Approaches to Biology, Gordon Research Conference, June 2006
- Interdisciplinary Teaching in Sciences, Engineering, and Social Sciences Workshop, Stanford University, April 12, 2006.
- Burroughs Wellcome Fund – Howard Hughes Medical Institute Course in Scientific Management, Chevy Chase, MD, June 6-10, 2005.
- Responsible Conduct of Research Course, Stanford University School of Medicine, January - March 2004.
- Boulder Summer School for Condensed Matter and Materials Physics: Physics of Soft Condensed Matter, University of Colorado, July 1-26, 2002.
- Co-founder and executive board member Women in Physics organization at the University of Pennsylvania, 1998-99.
- Member of: American Physical Society, American Society for Cell Biology, Biophysical Society, American Society of Mechanical Engineers
- Reviewer for: Science, Nature, Nature Methods, Nature Nanotechnology, Physical Review Letters, Biophysical Journal, Biochemistry, Cellular and Molecular Bioengineering, Current Biology, Cereal Chemistry, Garland Press